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Back in September, I developed a simple model to predict how many more Americans would die from COVID-19. Over this long weekend, I updated the model with numbers from the New York Times on Friday, November 26.

As I entered the numbers and watched the changes, I had questions about some of my assumptions, so I won’t post the whole spreadsheet the way I did in September. I think the bottom lines are no worse than any other projection. Across the US, 133,859,829 people remain susceptible. That’s 40% of the population. We need that to be closer to 10%. In September, the number was 147,194,141.

Although unvaccinated people have been filling hospitals, their numbers are not enough to make a big difference in those remaining susceptible to the disease. Additionally, evidence is mounting that having been infected with the virus produces less, shorter-lasting immunity than vaccination does.

I did not do a formal sensitivity analysis, but watching the numbers in the spreadsheet change made it obvious that vaccination is the biggest factor in decreasing the numbers of susceptible people. Over the next few weeks, we will see large numbers of children vaccinated, which will help, but children in the age group newly opened for vaccination number about 33 million.

South Africa has one of the best surveillance programs for the virus, and they have found a new variant, which the WHO has called Omicron. None of the things that we want to know – NOW! – are available, and they won’t be available for weeks. Omicron has many more mutations than previous variants, which means it’s been hiding out somewhere as those mutations piled up.

Which means that the earlier variants weren’t as transmissible as Delta. One of the things I am watching for is Omicron’s transmissibility relative to Delta. If it’s much less, it won’t replace Delta, no matter what its other characteristics.

Here’s a good summary of what is known about Omicron. And here’s WHO’s update. What you need to do is the same as before – get vaccinated, mask up, use testing before getting together with people. And tell your legislative representatives we need to vaccinate the world.

Cross-posted to Nuclear Diner

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